Biofilm compared to conventional antimicrobial susceptibility of Stenotrophomonas maltophilia Isolates from cystic fibrosis patients

Antimicrob Agents Chemother. 2013 Mar;57(3):1546-8. doi: 10.1128/AAC.02215-12. Epub 2013 Jan 7.

Abstract

Stenotrophomonas maltophilia is a multidrug-resistant organism increasingly isolated from the lungs of cystic fibrosis (CF) patients. One hundred twenty-five S. maltophilia isolates from 85 CF patients underwent planktonic and biofilm susceptibility testing against 9 different antibiotics, alone and in double antibiotic combinations. When S. maltophilia isolates were grown as a biofilm, 4 of the 10 most effective antibiotic combinations included high-dose levofloxacin and 7 of the 10 combinations included colistin at doses achievable by aerosolization.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Administration, Inhalation
  • Anti-Bacterial Agents / pharmacology
  • Anti-Bacterial Agents / therapeutic use*
  • Biofilms / drug effects*
  • Biofilms / growth & development
  • Child
  • Cystic Fibrosis / complications
  • Cystic Fibrosis / drug therapy*
  • Cystic Fibrosis / microbiology
  • Drug Resistance, Multiple, Bacterial / drug effects
  • Drug Therapy, Combination
  • Gram-Negative Bacterial Infections / complications
  • Gram-Negative Bacterial Infections / drug therapy*
  • Gram-Negative Bacterial Infections / microbiology
  • Humans
  • Microbial Sensitivity Tests
  • Plankton / drug effects*
  • Plankton / growth & development
  • Stenotrophomonas maltophilia / drug effects*
  • Stenotrophomonas maltophilia / growth & development
  • Stenotrophomonas maltophilia / isolation & purification

Substances

  • Anti-Bacterial Agents