Hydrogen sulfide, the next potent preventive and therapeutic agent in aging and age-associated diseases

Mol Cell Biol. 2013 Mar;33(6):1104-13. doi: 10.1128/MCB.01215-12. Epub 2013 Jan 7.


Hydrogen sulfide (H(2)S) is the third endogenous signaling gasotransmitter, following nitric oxide and carbon monoxide. It is physiologically generated by cystathionine-γ-lyase, cystathionine-β-synthase, and 3-mercaptopyruvate sulfurtransferase. H(2)S has been gaining increasing attention as an important endogenous signaling molecule because of its significant effects on the cardiovascular and nervous systems. Substantial evidence shows that H(2)S is involved in aging by inhibiting free-radical reactions, activating SIRT1, and probably interacting with the age-related gene Klotho. Moreover, H(2)S has been shown to have therapeutic potential in age-associated diseases. This article provides an overview of the physiological functions and effects of H(2)S in aging and age-associated diseases, and proposes the potential health and therapeutic benefits of H(2)S.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Age Factors
  • Aging / metabolism*
  • Animals
  • Cardiovascular System / drug effects*
  • Cardiovascular System / metabolism
  • Humans
  • Hydrogen Sulfide / metabolism*
  • Hydrogen Sulfide / pharmacology*
  • Hydrogen Sulfide / therapeutic use
  • Nervous System / drug effects*
  • Nervous System / metabolism
  • Oxidative Stress / drug effects
  • Signal Transduction / drug effects*


  • Hydrogen Sulfide