A world of cytochrome P450s

doi:10.1098/rstb.2012.0430

. 2013 Jan 6;368(1612):20120430.

doi: 10.1098/rstb.2012.0430. Print 2013 Feb 19.

A world of cytochrome P450s

David R Nelson¹

Affiliations

Affiliation

¹ Department of Microbiology, Immunology and Biochemistry, University of Tennessee Health Science Center, 858 Madison Avenue Suite G01, Memphis, TN 38163, USA. dnelson@uthsc.edu

PMID: 23297353
PMCID: PMC3538420
DOI: 10.1098/rstb.2012.0430

A world of cytochrome P450s

David R Nelson. Philos Trans R Soc Lond B Biol Sci. 2013.

. 2013 Jan 6;368(1612):20120430.

doi: 10.1098/rstb.2012.0430. Print 2013 Feb 19.

Author

David R Nelson¹

Affiliation

¹ Department of Microbiology, Immunology and Biochemistry, University of Tennessee Health Science Center, 858 Madison Avenue Suite G01, Memphis, TN 38163, USA. dnelson@uthsc.edu

PMID: 23297353
PMCID: PMC3538420
DOI: 10.1098/rstb.2012.0430

Abstract

The world we live in is a biosphere influenced by all organisms who inhabit it. It is also an ecology of genes, with some having rather startling effects. The premise put forth in this issue is cytochrome P450 is a significant player in the world around us. Life and the Earth itself would be visibly different and diminished without cytochrome P450s. The contributions to this issue range from evolution on the billion year scale to the colour of roses, from Darwin to Rachel Carson; all as seen through the lens of cytochrome P450.

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References

1. Klingenberg M. 1958. Pigments of rat liver microsomes. Arch. Biochem. Biophys. 75, 376–38610.1016/0003-9861(58)90436-3 (doi:10.1016/0003-9861(58)90436-3) - DOI - DOI - PubMed
1. Nelson DR. 2009. The cytochrome P450 homepage. Hum. Genomics. 4, 59–65 - PMC - PubMed
1. Stucken K, Ilhan J, Roettger M, Dagan T, Martin WF. 2012. Transformation and conjugal transfer of foreign genes into the filamentous multicellular cyanobacteria (subsection v) Fischerella and Chlorogloeopsis. Curr. Microbiol. 65, 552–56010.1007/s00284-012-0193-5 (doi:10.1007/s00284-012-0193-5) - DOI - DOI - PubMed
1. Cavalier-Smith T. 2006. Cell evolution and Earth history: stasis and revolution. Phil. Trans. R. Soc. B 361, 969–100610.1098/rstb.2006.1842 (doi:10.1098/rstb.2006.1842) - DOI - DOI - PMC - PubMed
1. Qiu Y, et al. 2012. An insect-specific P450 oxidative decarbonylase for cuticular hydrocarbon biosynthesis. Proc. Natl Acad. Sci. USA 109, 14 858–14 86310.1073/pnas.1208650109 (doi:10.1073/pnas.1208650109) - DOI - DOI - PMC - PubMed

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[1] Klingenberg M. 1958. Pigments of rat liver microsomes. Arch. Biochem. Biophys. 75, 376–38610.1016/0003-9861(58)90436-3 (doi:10.1016/0003-9861(58)90436-3) - DOI - DOI - PubMed

[2] Klingenberg M. 1958. Pigments of rat liver microsomes. Arch. Biochem. Biophys. 75, 376–38610.1016/0003-9861(58)90436-3 (doi:10.1016/0003-9861(58)90436-3) - DOI - DOI - PubMed

[3] Nelson DR. 2009. The cytochrome P450 homepage. Hum. Genomics. 4, 59–65 - PMC - PubMed

[4] Nelson DR. 2009. The cytochrome P450 homepage. Hum. Genomics. 4, 59–65 - PMC - PubMed

[5] Stucken K, Ilhan J, Roettger M, Dagan T, Martin WF. 2012. Transformation and conjugal transfer of foreign genes into the filamentous multicellular cyanobacteria (subsection v) Fischerella and Chlorogloeopsis. Curr. Microbiol. 65, 552–56010.1007/s00284-012-0193-5 (doi:10.1007/s00284-012-0193-5) - DOI - DOI - PubMed

[6] Stucken K, Ilhan J, Roettger M, Dagan T, Martin WF. 2012. Transformation and conjugal transfer of foreign genes into the filamentous multicellular cyanobacteria (subsection v) Fischerella and Chlorogloeopsis. Curr. Microbiol. 65, 552–56010.1007/s00284-012-0193-5 (doi:10.1007/s00284-012-0193-5) - DOI - DOI - PubMed

[7] Cavalier-Smith T. 2006. Cell evolution and Earth history: stasis and revolution. Phil. Trans. R. Soc. B 361, 969–100610.1098/rstb.2006.1842 (doi:10.1098/rstb.2006.1842) - DOI - DOI - PMC - PubMed

[8] Cavalier-Smith T. 2006. Cell evolution and Earth history: stasis and revolution. Phil. Trans. R. Soc. B 361, 969–100610.1098/rstb.2006.1842 (doi:10.1098/rstb.2006.1842) - DOI - DOI - PMC - PubMed

[9] Qiu Y, et al. 2012. An insect-specific P450 oxidative decarbonylase for cuticular hydrocarbon biosynthesis. Proc. Natl Acad. Sci. USA 109, 14 858–14 86310.1073/pnas.1208650109 (doi:10.1073/pnas.1208650109) - DOI - DOI - PMC - PubMed

[10] Qiu Y, et al. 2012. An insect-specific P450 oxidative decarbonylase for cuticular hydrocarbon biosynthesis. Proc. Natl Acad. Sci. USA 109, 14 858–14 86310.1073/pnas.1208650109 (doi:10.1073/pnas.1208650109) - DOI - DOI - PMC - PubMed

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A world of cytochrome P450s

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A world of cytochrome P450s

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