Previous studies have demonstrated that speech understanding in reverberant rooms improves when listeners are given prior exposure to the room. Results from these room-adaptation studies are limited, however, because they were conducted with materials that are not representative of the high acoustic variability observed in speech signals during everyday communication. Here, room adaptation effects were measured using an open-set speech corpus with high lexical and indexical variability and virtual auditory space techniques to simulate binaural listening in rooms. Room adaptation effects of comparable magnitude to previous studies were observed, suggesting general importance for facilitating speech intelligibility in reverberation.