Impact of neuropeptide substance P an inflammatory compound on arachidonic acid compound generation

Int J Immunopathol Pharmacol. 2012 Oct-Dec;25(4):849-57. doi: 10.1177/039463201202500403.


There is much evidence that neuropeptide substance P is involved in neurogenic inflammation and is an important neurotransmitter and neurmodulator compound. In addition, substance P plays an important role in inflammation and immunity. Macrophages can be activated by substance P which provokes the release of inflammatory compounds such as interleukins, chemokines and growth factors. Substance P is involved in the mechanism of pain through the trigeminal nerve which runs through the head, temporal and sinus cavity. Substance P also activates mast cells to release inflammatory mediators such as arachindonic acid compound, cytokines/chemokines and histamine. The release of these chemical mediators is crucial for inflammatory response. Among these mediators there are prostoglandins and leukotrines. Here we review the impact of substance P on inflammatory compounds.

Publication types

  • Editorial
  • Review

MeSH terms

  • Animals
  • Arachidonic Acid / biosynthesis*
  • Arachidonic Acid / immunology
  • Capillary Permeability
  • Dinoprostone / physiology
  • Humans
  • Receptors, Neurokinin-1 / physiology
  • Substance P / physiology*


  • Receptors, Neurokinin-1
  • Arachidonic Acid
  • Substance P
  • Dinoprostone