Tuning Wnt signals for more or fewer hairs

J Invest Dermatol. 2013 Jan;133(1):7-9. doi: 10.1038/jid.2012.446.


Activation of β-catenin was shown to be of central importance for hair development and cycling. Recent progress brought more understanding to how Wnt signaling is regulated during hair follicle generation and regeneration, telogen-anagen reentry, and extra-follicular macro-environmental modulation. This new understanding presents multiple possibilities to fine tune Wnt signaling for desired hair growth.

MeSH terms

  • Animals
  • Hair / growth & development*
  • Hair / physiology
  • Mice
  • Regeneration / physiology
  • Stem Cells / physiology
  • Wnt Proteins / metabolism*
  • Wnt Signaling Pathway*
  • beta Catenin / metabolism*


  • Wnt Proteins
  • beta Catenin