Raine eye health study: design, methodology and baseline prevalence of ophthalmic disease in a birth-cohort study of young adults

Ophthalmic Genet. 2013 Dec;34(4):199-208. doi: 10.3109/13816810.2012.755632. Epub 2013 Jan 10.

Abstract

Purpose: The Raine Eye Health Study (REHS) was conceived to determine the prevalence of and risk factors for eye disease in young adults, and to characterize ocular biometric parameters in a young adult cohort. This article summarizes the rationale and study design of REHS and outlines the baseline prevalence of ophthalmic disease in this population.

Methods: The Western Australian Pregnancy Cohort (Raine) Study originated as a randomized-controlled trial of 2900 women recruited from the state's largest maternity hospital. Their offspring (N = 2868) have been followed at birth, ages 1, 2, 3, 5, 8, 10, 14, 17 and 20 years of age in a prospective cohort study. DNA has been collected from participants for genome-wide association studies. At the 20-year follow-up participants completed a comprehensive eye assessment that included visual acuity, orthoptic assessment and cycloplegic autorefraction, as well as several ocular biometric variables and multiple ophthalmic photographs of the anterior and posterior segments.

Results: A total of 1344 participants (51.3% male) were assessed over a 24-month period. For the majority of examined participants (85.5%) both parents were Caucasian, 63.3% had completed school year 12 or equivalent, 5.5% had myopia (spherical equivalent ≤-3 diopters) and 15 participants (1.2%) had unilateral or bilateral pterygia. Keratoconus, cataract, keratitis and uveitis were rare.

Conclusion: The REHS design and methodology allow comparison with other population-based studies of eye disease. The study established the prevalence of eye disorders in a large sample of predominantly Caucasian young Australian adults.

Publication types

  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cohort Studies
  • European Continental Ancestry Group / ethnology*
  • Eye Diseases / ethnology*
  • Eye Diseases / genetics
  • Female
  • Follow-Up Studies
  • Genome-Wide Association Study
  • Health Surveys
  • Humans
  • Male
  • Prevalence
  • Prospective Studies
  • Research Design
  • Risk Factors
  • Surveys and Questionnaires
  • Visual Acuity / physiology
  • Western Australia / epidemiology
  • Young Adult