Integral Membrane Proteins and Bilayer Proteomics

Anal Chem. 2013 Mar 5;85(5):2558-68. doi: 10.1021/ac303064a. Epub 2013 Feb 19.


Integral membrane proteins reside within the bilayer membranes that surround cells and organelles, playing critical roles in movement of molecules across them and the transduction of energy and signals. While their extreme amphipathicity presents technical challenges, biological mass spectrometry has been applied to all aspects of membrane protein chemistry and biology, including analysis of primary, secondary, tertiary, and quaternary structures as well as the dynamics that accompany functional cycles and catalysis.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Cell Membrane / metabolism
  • Lipid Bilayers / metabolism*
  • Mass Spectrometry
  • Membrane Proteins / chemistry
  • Membrane Proteins / metabolism*
  • Molecular Sequence Data
  • Protein Processing, Post-Translational
  • Proteomics / methods*


  • Lipid Bilayers
  • Membrane Proteins