Role of platelets in neurodegenerative diseases: a universal pathophysiology

Int J Neurosci. 2013 May;123(5):287-99. doi: 10.3109/00207454.2012.751534. Epub 2013 Feb 6.


Platelets play an important role in a variety of disorders, namely, cardiovascular, psychosomatic, psychiatric, thrombosis, HIV/AIDS in addition to various neurodegenerative diseases (NDDs). Recent evidence indicates that platelet react to diverse stressors, thereby offering an interesting vantage point for understanding their potential role in contemporary medical research. This review addresses the possible role of platelets as a systemic probe in various NDDs, such as amyotrophic lateral sclerosis, Parkinson's disease, Huntington's disease, Alzheimer's disease, multiple sclerosis, etc. The current review based on published literature, describes a probable link between platelets and pathophysiology of various NDDs. It also discusses how platelets epitomize ultrastructural, morphological, biochemical and molecular changes, highlighting their emerging role as systemic tools in different NDDs.

Publication types

  • Review

MeSH terms

  • Animals
  • Biomarkers / blood
  • Blood Platelets / pathology*
  • Blood Platelets / physiology
  • Humans
  • Neurodegenerative Diseases / blood*
  • Neurodegenerative Diseases / pathology*
  • Neurodegenerative Diseases / physiopathology


  • Biomarkers