A case of recurrent psychosis during sickle cell disease crisis treated successfully with ziprasidone

Clin Schizophr Relat Psychoses. 2013 Jan;6(4):197-201. doi: 10.3371/CSRP.SPME.01062013.


We present and follow a series of three consecutive hospitalizations of a 36-year-old, African-American male with sickle cell anemia disease who presented with sickle cell crises and a new onset psychotic episode. After multiple hospitalizations for prior episodes of sickle cell crisis-induced pain, treated with rehydration, blood transfusions, and opiate medication, this hospitalization was the first time he developed psychosis. As such, we discuss the differential diagnosis of the latter, and effective adjunctive treatment with ziprasidone.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Analgesics, Opioid / therapeutic use
  • Anemia, Sickle Cell / complications*
  • Anemia, Sickle Cell / therapy
  • Antipsychotic Agents / therapeutic use*
  • Blood Transfusion / methods
  • Diagnosis, Differential
  • Fluid Therapy / methods
  • Hospitalization
  • Humans
  • Male
  • Pain / etiology
  • Pain Management / methods
  • Piperazines / therapeutic use*
  • Psychotic Disorders / complications
  • Psychotic Disorders / diagnosis
  • Psychotic Disorders / drug therapy*
  • Recurrence
  • Thiazoles / therapeutic use*


  • Analgesics, Opioid
  • Antipsychotic Agents
  • Piperazines
  • Thiazoles
  • ziprasidone