Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
, 14 (1), 1310-22

Phospholipids and Alzheimer's Disease: Alterations, Mechanisms and Potential Biomarkers

Affiliations
Review

Phospholipids and Alzheimer's Disease: Alterations, Mechanisms and Potential Biomarkers

Marko Kosicek et al. Int J Mol Sci.

Abstract

Brain is one of the richest organs in lipid content. Phospholipids (glycerophospholipids and sphingolipids) are important building blocks of cell membranes, which provide an optimal environment for protein interactions, trafficking and function. Because of that, alterations in their cellular levels could lead to different pathogenic processes in the brain, such as in Alzheimer's disease (AD), the most common type of dementia among older populations. There is increasing evidence that phospholipid changes occur during pathogenic processes in AD. It is known that lipids are tightly connected with metabolism of the Amyloid Precursor Protein (APP), which produces Amyloid-beta peptide (Aβ), the main component of senile plaques, which represent the main pathological hallmark of AD. However, the mechanism(s) of the lipid-effect on Aβ metabolism and AD pathogenesis is still not completely understood. This review summarizes the current knowledge on phospholipid changes occurring during normal aging and discusses phospholipid changes in the human brain associated with different stages of AD, as well changes in the cerebrospinal fluid and blood/plasma, which are interesting potential biomarkers for AD diagnosis and disease monitoring. At the end, we have discussed future perspectives of phospholipid changes as potential biomarkers and as targets for development of novel treatment strategies against AD.

Similar articles

See all similar articles

Cited by 36 PubMed Central articles

See all "Cited by" articles

References

    1. Veloso A., Fernandez R., Astigarraga E., Barreda-Gomez G., Manuel I., Giralt M.T., Ferrer I., Ochoa B., Rodriguez-Puertas R., Fernandez J.A. Distribution of Lipids in Human Brain. Anal. Bioanal. Chem. 2011;401:89–101. - PubMed
    1. Farooqui A.A., Liss L., Horrocks L.A. Neurochemical Aspects of Alzheimers-Disease: Involvement of Membrane Phospholipids. Metab. Brain Dis. 1988;3:19–35. - PubMed
    1. Soderberg M., Edlund C., Kristensson K., Dallner G. Lipid Compositions of Different Regions of the Human-Brain During Aging. J. Neurochem. 1990;54:415–423. - PubMed
    1. Svennerholm L., Bostrom K., Jungbjer B., Olsson L. Membrane-Lipids of Adult Human Brain: Lipid-Composition of Frontal and Temporal-Lobe in Subjects of Age 20 to 100 Years. J. Neurochem. 1994;63:1802–1811. - PubMed
    1. Svennerholm L., Bostrom K., Helander C.G., Jungbjer B. Membrane-Lipids in the Aging Human Brain. J. Neurochem. 1991;56:2051–2059. - PubMed
Feedback