Selective mutation in ATP-binding site reduces affinity of drug to the kinase: a possible mechanism of chemo-resistance

Med Oncol. 2013 Mar;30(1):448. doi: 10.1007/s12032-012-0448-9. Epub 2013 Jan 10.
No abstract available

Publication types

  • Letter

MeSH terms

  • Adenosine Triphosphate
  • Amino Acid Sequence
  • Binding Sites*
  • Drug Resistance, Neoplasm*
  • Humans
  • Models, Molecular*
  • Molecular Sequence Data
  • Mutation
  • Protein Kinase C / chemistry*
  • Protein Kinase C / genetics
  • Protein Structure, Tertiary

Substances

  • Adenosine Triphosphate
  • Protein Kinase C