Clinical and histologic effects of extreme intraocular hypothermia

Am J Ophthalmol. 1990 Apr 15;109(4):469-73. doi: 10.1016/s0002-9394(14)74615-x.


Rabbit eyes in which vitrectomy was performed underwent three hours of hypothermic perfusion with either 22 C or 2 C lactated Ringer's solution. Clinical, electroretinographic, fluorescein angiographic, histologic, and ultrastructural examinations were performed. No changes were noted in eyes cooled with 22 C fluid. Reversible lens opacities, equivocal electroretinographic changes, and subclinical retinal detachments were found in the eyes cooled with 2 C fluid. Extreme cooling of eyes is not advisable, although temperatures of 22 C are well tolerated.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Cataract / etiology
  • Cold Temperature / adverse effects
  • Electroretinography
  • Eye / pathology*
  • Eye / physiopathology
  • Fluorescein Angiography
  • Hypothermia, Induced* / adverse effects
  • Ophthalmologic Surgical Procedures
  • Rabbits
  • Retina / pathology
  • Retina / physiopathology
  • Retinal Detachment / etiology
  • Vitrectomy