To spread or not to spread--chromatin modifications in response to DNA damage

Curr Opin Genet Dev. 2013 Apr;23(2):156-65. doi: 10.1016/j.gde.2012.11.001. Epub 2013 Jan 9.

Abstract

Chromatin modifications in response to DNA damage are vital for genome integrity. Multiple proteins and pathways required to generate specialized chromatin domains around DNA lesions have been identified and the increasing amount of information calls for unifying concepts that would allow us to grasp the ever-increasing complexity. This review aims at contributing to this trend by focusing on feed-forward and feedback mechanisms, which in mammalian cells determine the extent of chromatin modifications after DNA damage. We highlight the emerging notion that the nodal points of these highly dynamic pathways operate in a rate-limiting mode, whose deregulation can disrupt physiological boundaries between damaged and undamaged chromatin, dictate repair pathway choice, and determine the fate of cells exposed to genotoxic stress.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Chromatin / genetics*
  • Chromatin / ultrastructure*
  • Chromatin Assembly and Disassembly
  • DNA / biosynthesis
  • DNA / genetics
  • DNA Damage / genetics*
  • DNA Repair / genetics
  • Genomic Instability*
  • Histones / genetics
  • Humans

Substances

  • Chromatin
  • Histones
  • DNA