Modeling cognitive dysfunction in neurofibromatosis-1

Trends Neurosci. 2013 Apr;36(4):237-47. doi: 10.1016/j.tins.2012.12.002. Epub 2013 Jan 8.


Cognitive dysfunction, including significant impairments in learning, behavior, and attention, is found in over 10% of children in the general population. However, in the common inherited cancer predisposition syndrome, neurofibromatosis type 1 (NF1), the prevalence of these cognitive deficits approaches 70%. As a monogenic disorder, NF1 provides a unique genetic tool to identify and dissect mechanistically the molecular and cellular bases underlying cognitive dysfunction. In this review, we discuss Nf1 fly and mouse systems that mimic many of the cognitive abnormalities seen in children with NF1. Further, we describe discoveries from these models that have uncovered defects in the regulation of Ras activity, cAMP generation, and dopamine homeostasis as key mechanisms important for cognitive dysfunction in children with NF1.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Animals
  • Cognition Disorders* / etiology
  • Cognition Disorders* / genetics
  • Cognition Disorders* / metabolism
  • Cyclic AMP / metabolism
  • Disease Models, Animal*
  • Humans
  • Neurofibromatosis 1 / genetics*
  • Neurofibromatosis 1 / metabolism
  • Signal Transduction


  • Cyclic AMP