Comparison of annual variability in HbA1c and glycated albumin in patients with type 1 vs. type 2 diabetes mellitus

J Diabetes Complications. 2013 May-Jun;27(3):211-3. doi: 10.1016/j.jdiacomp.2012.12.001. Epub 2013 Jan 10.


Objective: It has been suggested that plasma glucose (PG) levels per se and long-term variations in PG levels are associated with diabetic vascular complications. Glycated albumin (GA) reflects shorter-term glycemic control, as well as postprandial PG levels, as compared to HbA1c. In this study, we hypothesized that GA more strongly reflects long-term variations in PG levels than HbA1c, and compared the variability of HbA1c and that of GA in patients with type 1 diabetes mellitus (T1DM) and type 2 diabetes mellitus (T2DM).

Methods: This study included 8 T1DM patients and 48 T2DM patients. Over a 1-year period, HbA1c and GA were measured every month and the mean values and coefficients of variation (CV) for each patient were calculated.

Results: In both T1DM and T2DM patients, the CV of GA was significantly higher than the CV of HbA1c. Both the CV of HbA1c and the CV of GA were significantly higher in the T1DM patients than in the T2DM patients.

Conclusion: The annual variability in GA was greater than that in HbA1c. In addition, the annual variability in HbA1c and that in GA in the T1DM patients were greater than in the T2DM patients. Our findings suggest that GA more accurately reflects long-term variations in PG levels than HbA1c.

Publication types

  • Comparative Study
  • Multicenter Study

MeSH terms

  • Aged
  • Biomarkers / blood
  • Diabetes Mellitus, Type 1 / blood*
  • Diabetes Mellitus, Type 1 / complications
  • Diabetes Mellitus, Type 1 / therapy
  • Diabetes Mellitus, Type 2 / blood*
  • Diabetes Mellitus, Type 2 / complications
  • Diabetes Mellitus, Type 2 / therapy
  • Diabetic Angiopathies / epidemiology
  • Female
  • Glycated Hemoglobin A / analysis*
  • Glycation End Products, Advanced
  • Humans
  • Hyperglycemia / epidemiology*
  • Hyperglycemia / prevention & control
  • Japan / epidemiology
  • Male
  • Middle Aged
  • Risk Factors
  • Serum Albumin / analysis*


  • Biomarkers
  • Glycated Hemoglobin A
  • Glycation End Products, Advanced
  • Serum Albumin
  • glycated serum albumin
  • hemoglobin A1c protein, human