Triglyceride accumulation inhibitory effects of phenylpropanoid glycosides from Boschniakia rossica Fedtsch et Flerov

Fitoterapia. 2013 Mar:85:69-75. doi: 10.1016/j.fitote.2012.12.031. Epub 2013 Jan 10.

Abstract

Bioassay-guided fractionation led to isolation of five new phenylpropanol glycosides, rossicasides G (1), H (2), I (3), J (4), and K (5), together with seven known compounds (6-12) from Boschniakia rossica. Their structures were elucidated by chemical and spectroscopic methods (UV, IR, HRESI-TOF-MS, 1D and 2D NMR). Activity screening results showed that some isolates had TG accumulation inhibitory effects in HepG2 cells. Furthermore, the structure-activity relationship was partly clarified.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Obesity Agents / isolation & purification*
  • Disaccharides / chemistry
  • Disaccharides / isolation & purification*
  • Hep G2 Cells
  • Humans
  • Molecular Structure
  • Orobanchaceae / chemistry*
  • Plants, Medicinal / chemistry
  • Propanols / chemistry
  • Propanols / isolation & purification*
  • Structure-Activity Relationship
  • Triglycerides / metabolism

Substances

  • Anti-Obesity Agents
  • Disaccharides
  • Propanols
  • Triglycerides