Abstract
Screening investigations in antiviral action of plant extracts have revealed that a component of Glycyrrhiza glabra roots, found to be glycyrrhizie acid, is active against viruses. We report here that this drug inhibits growth and cytopathology of several unrelated DNA and RNA viruses, while not affecting cell activity and ability to replicate. In addition, glycyrrhizic acid inactivates herpes simplex virus particles irreversibly.
MeSH terms
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Antiviral Agents*
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Biological Transport / drug effects
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Cells, Cultured
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Glycyrrhetinic Acid / analogs & derivatives*
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Glycyrrhetinic Acid / pharmacology
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Glycyrrhiza*
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Glycyrrhizic Acid
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Plants, Medicinal*
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Poliovirus / drug effects
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Simplexvirus / drug effects
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Vaccinia virus / drug effects
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Vesicular stomatitis Indiana virus / drug effects
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Virus Replication / drug effects*
Substances
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Antiviral Agents
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Glycyrrhizic Acid
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Glycyrrhetinic Acid