A Heterozygous Moth Genome Provides Insights Into Herbivory and Detoxification

Nat Genet. 2013 Feb;45(2):220-5. doi: 10.1038/ng.2524. Epub 2013 Jan 13.

Abstract

How an insect evolves to become a successful herbivore is of profound biological and practical importance. Herbivores are often adapted to feed on a specific group of evolutionarily and biochemically related host plants, but the genetic and molecular bases for adaptation to plant defense compounds remain poorly understood. We report the first whole-genome sequence of a basal lepidopteran species, Plutella xylostella, which contains 18,071 protein-coding and 1,412 unique genes with an expansion of gene families associated with perception and the detoxification of plant defense compounds. A recent expansion of retrotransposons near detoxification-related genes and a wider system used in the metabolism of plant defense compounds are shown to also be involved in the development of insecticide resistance. This work shows the genetic and molecular bases for the evolutionary success of this worldwide herbivore and offers wider insights into insect adaptation to plant feeding, as well as opening avenues for more sustainable pest management.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adaptation, Biological / genetics*
  • Animals
  • Base Sequence
  • China
  • Chromosomes, Artificial, Bacterial
  • Computational Biology
  • Evolution, Molecular
  • Expressed Sequence Tags
  • Female
  • Gene Expression Profiling
  • Genetic Variation*
  • Genome / genetics*
  • Glucosinolates / metabolism*
  • Herbivory / genetics*
  • Heterozygote*
  • Male
  • Molecular Sequence Annotation
  • Molecular Sequence Data
  • Moths / genetics*
  • Moths / metabolism
  • Mutation / genetics
  • Pest Control / methods
  • Phylogeny*
  • Polymorphism, Single Nucleotide
  • Real-Time Polymerase Chain Reaction
  • Sequence Analysis, DNA
  • Sulfatases / genetics

Substances

  • Glucosinolates
  • Sulfatases

Associated data

  • GENBANK/AHIO00000000