Motor response of the human isolated small intestine and urinary bladder to porcine neuromedin U-8

Br J Pharmacol. 1990 Jan;99(1):186-8. doi: 10.1111/j.1476-5381.1990.tb14675.x.


1. Porcine neuromedin U-8 produced a concentration (0.3 nM-1 microM)-dependent contraction of the longitudinal muscle of the human isolated ileum, which was unaffected by either atropine (1 microM) or tetrodotoxin (1 microM). 2. By contrast, neuromedin U-8 had only a weak effect on the circular muscle of the human isolated ileum. 3. Neuromedin U-8 also produced a concentration-dependent contraction of mucosa-free muscle strips from the dome of the human isolated urinary bladder, its action being unaffected by either atropine or tetrodotoxin. 4. These findings indicate that neuromedin U-8 exerts a direct contractile effect on smooth muscle of the human intestinal and urinary tract.

MeSH terms

  • Aged
  • Animals
  • Electric Stimulation
  • Humans
  • In Vitro Techniques
  • Intestine, Small / drug effects
  • Middle Aged
  • Muscle Contraction / drug effects
  • Muscle, Smooth / drug effects*
  • Neuropeptides / pharmacology*
  • Swine
  • Urinary Bladder / drug effects


  • Neuropeptides
  • neuromedin U 8