Abstract
Autoimmune bullous skin disorders are characterized by a severe and potentially lethal course and may require aggressive long-term treatment with systemic corticosteroids and other immunosuppressive drugs, which can lead to serious adverse events. Recently, anti-CD20 antibody, Rituximab, was reported to be beneficial as an adjuvant therapy in these diseases. Herein, we present 2 case reports of patients suffering from resistant rare diseases from the aforementioned spectrum: linear IgA dermatosis and Pemphigoid gestationis. The patients were successfully treated with Rituximab (Mabthera). This is one of the first reports of this kind of treatment for these rare life-threatening diseases. These case reports emphasize the role of Rituximab as a crisis therapy in autoimmune blistering diseases.
Publication types
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Case Reports
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English Abstract
MeSH terms
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Adult
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Anemia, Hemolytic / chemically induced
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Anti-Infective Agents / administration & dosage
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Anti-Infective Agents / adverse effects
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Antibodies, Monoclonal, Murine-Derived / administration & dosage*
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Biopsy
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Dapsone / administration & dosage
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Dapsone / adverse effects
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Drug Resistance
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Female
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Fluorescent Antibody Technique, Direct / methods
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Glucocorticoids / administration & dosage
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Humans
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Immunologic Factors / administration & dosage
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Linear IgA Bullous Dermatosis* / drug therapy
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Linear IgA Bullous Dermatosis* / immunology
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Linear IgA Bullous Dermatosis* / pathology
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Linear IgA Bullous Dermatosis* / physiopathology
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Pemphigoid Gestationis* / drug therapy
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Pemphigoid Gestationis* / immunology
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Pemphigoid Gestationis* / pathology
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Pemphigoid Gestationis* / physiopathology
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Prednisone / administration & dosage
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Pregnancy
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Pruritus / etiology
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Rare Diseases / drug therapy
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Rare Diseases / immunology
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Rare Diseases / pathology
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Rare Diseases / physiopathology
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Rituximab
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Severity of Illness Index
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Skin / drug effects
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Skin / pathology*
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Treatment Outcome
Substances
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Anti-Infective Agents
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Antibodies, Monoclonal, Murine-Derived
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Glucocorticoids
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Immunologic Factors
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Rituximab
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Dapsone
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Prednisone