Comparative evaluation of autologous platelet-rich fibrin and platelet-rich plasma in the treatment of mandibular degree II furcation defects: a randomized controlled clinical trial

J Periodontal Res. 2013 Oct;48(5):573-81. doi: 10.1111/jre.12040. Epub 2013 Jan 14.


Background: The treatment of molar furcation defects remains a considerable challenge in clinical practice. The identification of clinical measurements influential to treatment outcomes is critical to optimize the results of surgical periodontal therapy. The present study aimed to explore the clinical and radiographical effectiveness of autologous platelet-rich fibrin (PRF) and autologous platelet-rich plasma (PRP) in the treatment of mandibular degree II furcation defects in subjects with chronic periodontitis.

Material and methods: Seventy-two mandibular degree II furcation defects were treated with either autologous PRF with open flap debridement (OFD; 24 defects) or autologous PRP with OFD (25), or OFD alone (23). Clinical and radiological parameters such as probing depth, relative vertical clinical attachment level and horizontal clinical attachment level along with gingival marginal level were recorded at baseline and 9 mo postoperatively.

Results: All clinical and radiographic parameters showed statistically significant improvement at both the test sites (PRF with OFD and PRP with OFD) compared to those with OFD alone. Relative vertical clinical attachment level gain was also greater in PRF (2.87 ± 0.85 mm) and PRP (2.71 ± 1.04 mm) sites as compared to control site (1.37 ± 0.58 mm), and relative horizontal clinical attachment level gain was statistically significantly greater in both PRF and PRP than in the control group.

Conclusions: The use of autologous PRF or PRP were both effective in the treatment of furcation defects with uneventful healing of sites.

Keywords: chronic periodontitis; periodontal surgery; regeneration.

Publication types

  • Comparative Study
  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Autografts / transplantation*
  • Blood Transfusion, Autologous / methods
  • Bone Regeneration / physiology
  • Chronic Periodontitis / surgery
  • Debridement / methods
  • Dental Plaque Index
  • Female
  • Fibrin / therapeutic use*
  • Follow-Up Studies
  • Furcation Defects / surgery*
  • Gingival Recession / surgery
  • Humans
  • Male
  • Mandibular Diseases / surgery*
  • Molar / surgery*
  • Periodontal Attachment Loss / surgery
  • Periodontal Index
  • Periodontal Pocket / surgery
  • Platelet Transfusion / methods
  • Platelet-Rich Plasma / physiology*
  • Surgical Flaps / surgery
  • Treatment Outcome


  • Fibrin