Effects of zinc L-carnosine on gastric mucosal and cell damage caused by ethanol in rats. Correlation with endogenous prostaglandin E2

Dig Dis Sci. 1990 May;35(5):559-66. doi: 10.1007/BF01540402.


The effects of zinc L-carnosine on ethanol-induced damage and the correlation of these effects with endogenous prostaglandin E2 were evaluated in rat gastric mucosa in vivo and in vitro. When given either intragastrically or intraperitoneally, zinc L-carnosine (10 or 30 mg/kg) prevented gross visible damage to gastric mucosa caused by ethanol without affecting the mucosal prostaglandin E2 level. This protective effect of zinc L-carnosine was not inhibited by indomethacin. Histological assessment showed that zinc L-carnosine inhibited deep mucosal necrosis, as did 16,16-dimethyl prostaglandin E2. Zinc L-carnosine (10(-6) or 10(-5) M) inhibited the damage caused by ethanol to gastric cells isolated from rat gastric mucosa in vitro; this effect was not inhibited by indomethacin. The results suggested that zinc L-carnosine protects the gastric mucosa and enhances cellular resistance to ethanol without the mediation of endogenous prostaglandins.

MeSH terms

  • 16,16-Dimethylprostaglandin E2 / pharmacology
  • Animals
  • Anti-Ulcer Agents / therapeutic use*
  • Carnosine / therapeutic use*
  • Dinoprostone / metabolism*
  • Dipeptides / therapeutic use*
  • Ethanol / antagonists & inhibitors
  • Ethanol / toxicity*
  • Gastric Mucosa / drug effects*
  • Gastric Mucosa / metabolism
  • Gastric Mucosa / pathology
  • Indomethacin / pharmacology
  • Rats
  • Rats, Inbred Strains
  • Stomach Ulcer / chemically induced
  • Stomach Ulcer / pathology
  • Stomach Ulcer / prevention & control*
  • Zinc / therapeutic use*


  • Anti-Ulcer Agents
  • Dipeptides
  • Ethanol
  • Carnosine
  • Zinc
  • Dinoprostone
  • 16,16-Dimethylprostaglandin E2
  • Indomethacin