Collagen stimulating effect of peptide amphiphile C16-KTTKS on human fibroblasts

Mol Pharm. 2013 Mar 4;10(3):1063-9. doi: 10.1021/mp300549d. Epub 2013 Feb 4.


The collagen production of human dermal and corneal fibroblasts in contact with solutions of the peptide amphiphile (PA) C16-KTTKS is investigated and related to its self-assembly into nanotape structures. This PA is used in antiwrinkle cosmeceutical applications (trade name Matrixyl). We prove that C16-KTTKS stimulates collagen production in a concentration-dependent manner close to the critical aggregation concentration determined from pyrene fluorescence spectroscopy. This suggests that self-assembly and the stimulation of collagen production are inter-related.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cells, Cultured
  • Collagen / metabolism*
  • Cornea / cytology
  • Dermis / cytology
  • Fibroblasts / drug effects*
  • Fibroblasts / metabolism*
  • Humans
  • Oligopeptides / pharmacology*
  • Spectrometry, Fluorescence


  • Oligopeptides
  • lysyl-threonyl-threonyl-lysyl-serine
  • Collagen