Crystallization and dissolution behavior of naproxen/polyethylene glycol solid dispersions

J Phys Chem B. 2013 Feb 7;117(5):1494-500. doi: 10.1021/jp3106716. Epub 2013 Jan 25.


The crystallization kinetics of naproxen (NAP) in NAP/polyethylene glycol (NAP/PEG) solid dispersions prepared at different crystallization temperatures was studied by in situ small-angle X-ray scattering/wide-angle X-ray scattering (SAXS/WAXS). It was found that the crystallization rate of NAP was faster at 25 °C in comparison to 40 °C. This resulted in different sizes of NAP domains, and consequently impacted the dissolution behavior. The sizes of NAP domains prepared at 40 °C were larger than those at 25 °C, as determined with surface area analysis, utilizing second-order nonlinear optical imaging of chiral crystals (SONICC). Consistent with this observation, the corresponding dissolution rate of the NAP/PEG dispersion prepared at 40 °C was indeed slower than that prepared at 25 °C. The microstructure of the NAP/PEG solid dispersions and the dissolution behavior also showed a dependence on the chemical composition of the solid dispersions.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Chemistry, Pharmaceutical
  • Crystallization
  • Kinetics
  • Naproxen / chemistry*
  • Polyethylene Glycols / chemistry*
  • Solubility
  • Water / chemistry


  • Water
  • Polyethylene Glycols
  • Naproxen