West Nile virus infection and immunity

Nat Rev Microbiol. 2013 Feb;11(2):115-28. doi: 10.1038/nrmicro2950.


West Nile virus (WNV) is an emerging neurotropic flavivirus that is transmitted to humans through the bite of an infected mosquito. WNV has disseminated broadly in the Western hemisphere and now poses a significant public health risk. The continuing spread of WNV, combined with the lack of specific therapeutics or vaccines to combat or prevent infection, imparts a pressing need to identify the viral and host processes that control the outcome of and immunity to WNV infection. Here, we provide an overview of recent research that has revealed the virus-host interface controlling WNV infection and immunity.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adaptive Immunity
  • Americas / epidemiology
  • Animals
  • Host-Pathogen Interactions / immunology
  • Immunity, Innate
  • West Nile Fever / epidemiology*
  • West Nile Fever / immunology
  • West Nile Fever / pathology
  • West Nile virus / immunology*
  • West Nile virus / physiology