CXCL13 is a biomarker of inflammation in multiple sclerosis, neuromyelitis optica, and other neurological conditions

Mult Scler. 2013 Aug;19(9):1204-8. doi: 10.1177/1352458512473362. Epub 2013 Jan 15.


CXCL13, a B-cell chemokine, has been proposed as a biomarker in a variety of conditions, some of which can mimic multiple sclerosis and can have very high levels. In this case-control study, cerebrospinal fluid (CSF) CXCL13 was elevated in multiple sclerosis, neuromyelitis optica and other inflammatory neurological controls compared with noninflammatory controls. Levels did not differentiate disease groups. For all subjects taken together, CSF CXCL13 correlated with CSF WBC, oligoclonal band numbers, CSF protein, EDSS, and neurofilament levels. In subgroup analyses, CSF CXCL13 correlated with CSF WBC in neuromyelitis optica and IgG index in multiple sclerosis. Additionally, serum CXCL13 was elevated in neuromyelitis optica.

Keywords: CXCL13; Multiple sclerosis; biomarker; myelin basic protein; neurofilament; neuroinflammation; neuromyelitis optica.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Biomarkers / analysis*
  • Case-Control Studies
  • Chemokine CXCL13 / analysis*
  • Chemokine CXCL13 / metabolism
  • Enzyme-Linked Immunosorbent Assay
  • Female
  • Humans
  • Inflammation / metabolism*
  • Male
  • Multiple Sclerosis / metabolism*
  • Neuromyelitis Optica / metabolism*


  • Biomarkers
  • CXCL13 protein, human
  • Chemokine CXCL13