Prognostic significance of volume-based PET parameters in cancer patients

Korean J Radiol. 2013 Jan-Feb;14(1):1-12. doi: 10.3348/kjr.2013.14.1.1. Epub 2012 Dec 28.


Accurate prediction of cancer prognosis before the start of treatment is important since these predictions often affect the choice of treatment. Prognosis is usually based on anatomical staging and other clinical factors. However, the conventional system is not sufficient to accurately and reliably determine prognosis. Metabolic parameters measured by (18)F-fluorodeoxyglucose (FDG) positron emission tomography (PET) have the potential to provide valuable information regarding prognosis and treatment response evaluation in cancer patients. Among these parameters, volume-based PET parameters such as metabolic tumor volume and total lesion glycolysis are especially promising. However, the measurement of these parameters is significantly affected by the imaging methodology and specific image characteristics, and a standard method for these parameters has not been established. This review introduces volume-based PET parameters as potential prognostic indicators, and highlights methodological considerations for measurement, potential implications, and prospects for further studies.

Keywords: 18F-fluorodeoxyglucose; Metabolic tumor volume; Positron emission tomography; Prognosisrinogenesis; Total lesion glycolysis.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Fluorodeoxyglucose F18
  • Glycolysis
  • Humans
  • Neoplasm Staging
  • Neoplasms / diagnostic imaging*
  • Neoplasms / pathology
  • Positron-Emission Tomography*
  • Predictive Value of Tests
  • Prognosis
  • Radiopharmaceuticals
  • Tumor Burden


  • Radiopharmaceuticals
  • Fluorodeoxyglucose F18