[Effect of 3-oxypyridine and succinic acid derivatives on affective status in recrudescence of inflammatory diseases of uterus and its appendages]

Eksp Klin Farmakol. 2012;75(11):22-7.
[Article in Russian]

Abstract

Short-term, prospective placebo-controlled simple blind randomized study of the effects of 3-oxypyridine and succinic acid derivatives (emoxipin, reamberin, mexidol) on the affective status of females with recrudescence of the inflammatory diseases of uterus and its appendages (IDUA) in comparison to changes of systemic inflammatory response (SIR) markers level in the blood has been conducted. It is established that the inclusion of emoxipin, reamberin and mexidol in complex treatment of IDUA recrudescence reduce depression, anxiety and SIR laboratory signs. Mexidol being both 3-oxypyridine and succinic acid derivative showed the best influence on the dynamics of affective disorders and SIR changes.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Adnexa Uteri / drug effects
  • Adnexa Uteri / immunology
  • Adolescent
  • Adult
  • Antioxidants / pharmacology
  • Antioxidants / therapeutic use
  • Brain / drug effects
  • Brain / immunology
  • Depressive Disorder / complications
  • Depressive Disorder / drug therapy*
  • Depressive Disorder / immunology
  • Female
  • Genital Diseases, Female / complications
  • Genital Diseases, Female / drug therapy*
  • Genital Diseases, Female / immunology
  • Humans
  • Inflammation / complications
  • Inflammation / drug therapy
  • Inflammation / immunology
  • Interleukin-1beta / blood
  • Meglumine / analogs & derivatives
  • Meglumine / pharmacology
  • Meglumine / therapeutic use
  • Middle Aged
  • Phagocytosis
  • Picolines / pharmacology*
  • Picolines / therapeutic use
  • Prospective Studies
  • Pyridines / pharmacology*
  • Pyridines / therapeutic use
  • Recurrence
  • Succinates / pharmacology
  • Succinates / therapeutic use
  • Succinic Acid / pharmacology*
  • Succinic Acid / therapeutic use
  • Tumor Necrosis Factor-alpha / blood
  • Uterus / drug effects
  • Uterus / immunology

Substances

  • 3-oxypyridine
  • Antioxidants
  • Interleukin-1beta
  • Picolines
  • Pyridines
  • Reamberin
  • Succinates
  • Tumor Necrosis Factor-alpha
  • emoxypine succinate
  • Meglumine
  • Succinic Acid
  • 6-methyl-2-ethyl-3-hydroxypyridine