Abstract
Six new carboxylic acids (1-6), together with 11 known ones (7-17), were isolated from the aerial parts of Lysimachia clethroides. Their structures were elucidated on the basis of spectroscopic analysis and chemical evidence. Five new carboxylic acids (1 and 3-6) were evaluated for their in vitro inhibitory activity against aldose reductase.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Aldehyde Reductase / antagonists & inhibitors*
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Carboxylic Acids / chemistry
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Carboxylic Acids / isolation & purification*
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Carboxylic Acids / pharmacology*
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Drugs, Chinese Herbal / chemistry
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Drugs, Chinese Herbal / isolation & purification*
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Drugs, Chinese Herbal / pharmacology*
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
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Primulaceae / chemistry*
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Structure-Activity Relationship
Substances
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Carboxylic Acids
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Drugs, Chinese Herbal
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Aldehyde Reductase