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. 2013 Jan 17;493(7432):318-26.
doi: 10.1038/nature11859.

Cytosystems Dynamics in Self-Organization of Tissue Architecture


Cytosystems Dynamics in Self-Organization of Tissue Architecture

Yoshiki Sasai. Nature. .


Our knowledge of the principles by which organ architecture develops through complex collective cell behaviours is still limited. Recent work has shown that the shape of such complex tissues as the optic cup forms by self-organization in vitro from a homogeneous population of stem cells. Multicellular self-organization involves three basic processes that are crucial for the emergence of latent intrinsic order. Based on lessons from recent studies, cytosystems dynamics is proposed as a strategy for understanding collective multicellular behaviours, incorporating four-dimensional measurement, theoretical modelling and experimental reconstitution.

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