Abstract
The mechanism of beta-adrenergic relaxation was investigated in isolated smooth muscle cells. Beta-adrenergic agents stimulate cyclic AMP-dependent phosphorylation, enhance Na+/K+ transport and induce relaxation. The stimulation of Na+/K+ transport is obligatory for relaxation, and we suggest that this stimulation induces relaxation through enhanced Na+/Ca2+ exchange.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Biological Transport, Active
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Bufo marinus
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Calcium / physiology
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Cyclic AMP / metabolism
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Isoproterenol / pharmacology
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Muscle Contraction* / drug effects
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Muscle Relaxation* / drug effects
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Muscle, Smooth / physiology*
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Potassium / physiology
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Protein Kinases / metabolism
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Receptors, Adrenergic / physiology*
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Receptors, Adrenergic, beta / physiology*
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Sodium / physiology
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Sodium-Potassium-Exchanging ATPase / metabolism
Substances
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Receptors, Adrenergic
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Receptors, Adrenergic, beta
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Sodium
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Cyclic AMP
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Protein Kinases
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Sodium-Potassium-Exchanging ATPase
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Isoproterenol
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Potassium
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Calcium