Dedifferentiation, transdifferentiation, and reprogramming: future directions in regenerative medicine

Semin Reprod Med. 2013 Jan;31(1):82-94. doi: 10.1055/s-0032-1331802. Epub 2013 Jan 17.


The main goal of regenerative medicine is to replace damaged tissue. To do this it is necessary to understand in detail the whole regeneration process including differentiated cells that can be converted into progenitor cells (dedifferentiation), cells that can switch into another cell type (transdifferentiation), and somatic cells that can be induced to become pluripotent cells (reprogramming). By studying the regenerative processes in both nonmammal and mammal models, natural or artificial processes could underscore the molecular and cellular mechanisms behind these phenomena and be used to create future regenerative strategies for humans.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Cell Dedifferentiation / physiology
  • Cell Transdifferentiation / physiology
  • Cellular Reprogramming / physiology*
  • Humans
  • Induced Pluripotent Stem Cells / cytology*
  • Induced Pluripotent Stem Cells / physiology
  • Regenerative Medicine / methods*