Double-hit mantle cell lymphoma with MYC gene rearrangement or amplification: a report of four cases and review of the literature

Int J Clin Exp Pathol. 2013;6(2):155-67. Epub 2013 Jan 15.


Mature B-cell lymphomas with both BCL2 and MYC translocations are known as "double hit" lymphomas. These lymphomas are aggressive and show high proliferation rate due to the growth advantages provided by MYC and BCL2 translocation and overexpression. Mantle cell lymphoma (MCL) is a neoplasm of mature B-lymphocytes with characteristic t(11;14) and subsequent Cyclin D1 overexpression. Secondary cytogenetic changes are frequent in MCL, but MYC translocation has only been rarely reported. In this study, we report four cases of MCL with MYC translocation or MYC gene amplification detected by conventional cytogenetics, fluorescence in situ hybridization and whole genome single nucleotide polymorphism (SNP) array, and determined the clinicopathologic features. Our study provides further evidence supporting the concept of "double hit" MCL with co-involvement of MYC gene rearrangement and/or amplification and CCND1 gene rearrangement.

Keywords: 8q24; MYC; Mantle cell lymphoma; amplification; double hit lymphoma; translocation.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Aged
  • Aged, 80 and over
  • Cyclin D1 / genetics
  • Female
  • Gene Amplification / genetics*
  • Gene Rearrangement, B-Lymphocyte / genetics*
  • Humans
  • Lymphoma, Mantle-Cell / genetics*
  • Lymphoma, Mantle-Cell / pathology
  • Male
  • Middle Aged
  • Proto-Oncogene Proteins c-myc / genetics*


  • CCND1 protein, human
  • MYC protein, human
  • Proto-Oncogene Proteins c-myc
  • Cyclin D1