Abstract
Cardioprotective properties of dimethyl sulfoxide (DMSO) were studied in the isolated rat heart model. Intraperitoneal administration of DMSO to animals for 3 days before the experiment, but not addition of DMSO to the perfusate, reduced infarction size. Both intraperitoneal and intracoronary administration of DMSO reduced the severity of postischemic left-ventricular dysfunction.
MeSH terms
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Animals
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Cardiotonic Agents / pharmacology*
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Dimethyl Sulfoxide / pharmacology*
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Heart / physiopathology
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Heart Ventricles / drug effects
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Male
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Myocardial Contraction
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Myocardial Infarction / drug therapy*
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Myocardial Reperfusion Injury / drug therapy
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Myocardial Reperfusion Injury / physiopathology
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Myocardial Reperfusion Injury / prevention & control*
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Rats
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Rats, Wistar
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Ventricular Dysfunction, Left / drug therapy
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Ventricular Function, Left / drug effects
Substances
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Cardiotonic Agents
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Dimethyl Sulfoxide