Abstract
We studied the effect of liposome preparation containing taxifolin oligomers and taxifolin conjugates with carbonyl compounds on skin regeneration after chemical burn. The preparations containing flavonoid conjugates intensified regeneration processes and reparation of hair follicles and sebaceous glands after chemical burn. The preparation based on taxifolin conjugate with acetaldehyde was most effective; its activity was comparable with that of the wound-healing preparation Olasol. Taxifolin conjugates with carbonyl compounds can be used for the creation of combined wound- and burn-healing preparations.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acetaldehyde / chemistry
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Acetaldehyde / therapeutic use*
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Animals
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Burns, Chemical / drug therapy*
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Flavonoids / pharmacology
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Flavonoids / therapeutic use
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Hair Follicle / drug effects
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Hair Follicle / growth & development
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Liposomes
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Male
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Quercetin / analogs & derivatives*
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Quercetin / pharmacology
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Quercetin / therapeutic use
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Rats
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Rats, Wistar
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Regeneration / drug effects*
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Sebaceous Glands / drug effects
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Sebaceous Glands / growth & development
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Skin / growth & development*
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Skin / injuries*
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Skin / metabolism
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Wound Healing / drug effects
Substances
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Flavonoids
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Liposomes
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Quercetin
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taxifolin
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Acetaldehyde