Cerebral vasculitis and multi-focal neurological deficits due to allopurinol-induced hypersensitivity syndrome

Abstract

Drug-induced hypersensitivity syndrome (DIHS) is a multi-system syndrome resulting from an idiosyncratic reaction to medication. While it commonly results in multi-organ involvement, particularly the liver, there are few reports of DIHS causing cerebral vasculitis and neurological deficits. We report the case of a 63-year old woman with DIHS secondary to allopurinol leading to multiple neurological deficits with magnetic resonance imaging findings consistent with a cerebral vasculitis.

Keywords: adverse drug reaction; drug reaction with eosinophilia and systemic symptom; drug-induced hypersensitivity syndrome.