Human Hemato-Lymphoid System Mice: Current Use and Future Potential for Medicine

Annu Rev Immunol. 2013;31:635-674. doi: 10.1146/annurev-immunol-032712-095921. Epub 2013 Jan 16.

Abstract

To directly study complex human hemato-lymphoid system physiology and respective system-associated diseases in vivo, human-to-mouse xenotransplantation models for human blood and blood-forming cells and organs have been developed over the past three decades. We here review the fundamental requirements and the remarkable progress made over the past few years in improving these systems, the current major achievements reached by use of these models, and the future challenges to more closely model and study human health and disease and to achieve predictive preclinical testing of both prevention measures and potential new therapies.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Hematopoiesis / immunology*
  • Hematopoietic Stem Cell Transplantation / methods
  • Hematopoietic Stem Cell Transplantation / trends
  • Humans
  • Immunophenotyping
  • Lymphoid Tissue / immunology*
  • Lymphoid Tissue / pathology
  • Lymphoid Tissue / transplantation*
  • Mice
  • Models, Animal*
  • Translational Medical Research / methods
  • Translational Medical Research / trends
  • Transplantation, Heterologous