Comparison of Bayesian and frequentist meta-analytical approaches for analyzing time to event data

J Biopharm Stat. 2013;23(1):129-45. doi: 10.1080/10543406.2013.737210.

Abstract

Using meta-analysis in health care research is a common practice. Here we are interested in methods used for analysis of time-to-event data. Particularly, we are interested in their performance when there is a low event rate. We consider three methods based on the Cox proportional hazards model, including a Bayesian approach. A formal comparison of the methods is conducted using a simulation study. In our simulation we model two treatments and consider several scenarios.

Publication types

  • Comparative Study

MeSH terms

  • Bayes Theorem
  • Clinical Trials as Topic / methods
  • Computer Simulation / trends
  • Humans
  • Meta-Analysis as Topic*
  • Proportional Hazards Models
  • Research Design*
  • Statistics as Topic / methods*
  • Time Factors