The regulatory roles of small leucine-rich proteoglycans in extracellular matrix assembly

FEBS J. 2013 May;280(10):2120-37. doi: 10.1111/febs.12136. Epub 2013 Feb 14.


Small leucine-rich proteoglycans (SLRPs) are involved in a variety of biological and pathological processes. This review focuses on their regulatory roles in matrix assembly. SLRPs have protein cores and hypervariable glycosylation with multivalent binding abilities. During development, differential interactions of SLRPs with other molecules result in tissue-specific spatial and temporal distributions. The changing expression patterns play a critical role in the regulation of tissue-specific matrix assembly and therefore tissue function. SLRPs play significant structural roles within extracellular matrices. In addition, they play regulatory roles in collagen fibril growth, fibril organization and extracellular matrix assembly. Moreover, they are involved in mediating cell-matrix interactions. Abnormal SLRP expression and/or structures result in dysfunctional extracellular matrices and pathophysiology. Altered expression of SLRPs has been found in many disease models, and structural deficiency also causes altered matrix assembly. SLRPs regulate assembly of the extracellular matrix, which defines the microenvironment, modulating both the extracellular matrix and cellular functions, with an impact on tissue function.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Chondroitin Sulfate Proteoglycans / metabolism
  • Collagen / metabolism
  • Cornea / metabolism
  • Cornea / pathology
  • Corneal Dystrophies, Hereditary / metabolism
  • Corneal Dystrophies, Hereditary / physiopathology
  • Extracellular Matrix / metabolism*
  • Humans
  • Keratan Sulfate / metabolism
  • Leucine / metabolism*
  • Lumican
  • Protein Binding
  • Protein Interaction Mapping
  • Protein Transport
  • Proteoglycans / deficiency
  • Proteoglycans / metabolism*
  • Tendons / metabolism


  • Chondroitin Sulfate Proteoglycans
  • LUM protein, human
  • Lumican
  • Proteoglycans
  • Collagen
  • Keratan Sulfate
  • Leucine

Supplementary concepts

  • Corneal Dystrophy, Congenital Stromal