A historical to present-day account of efforts to answer the question: "what puts the brakes on mammalian hair cell regeneration?"

Hear Res. 2013 Mar;297:52-67. doi: 10.1016/j.heares.2013.01.005. Epub 2013 Jan 17.


Hearing and balance deficits often affect humans and other mammals permanently, because their ears stop producing hair cells within a few days after birth. But production occurs throughout life in the ears of sharks, bony fish, amphibians, reptiles, and birds allowing them to replace lost hair cells and quickly recover after temporarily experiencing the kinds of sensory deficits that are irreversible for mammals. Since the mid 1970s, researchers have been asking what puts the brakes on hair cell regeneration in mammals. Here we evaluate the headway that has been made and assess current evidence for alternative mechanistic hypotheses that have been proposed to account for the limits to hair cell regeneration in mammals.

Publication types

  • Historical Article
  • Review

MeSH terms

  • Animals
  • Birds
  • Cell Cycle
  • Cell Differentiation
  • Cell Lineage
  • Cell Proliferation
  • Chickens
  • Developmental Biology / history*
  • Fishes
  • Gene Expression Regulation, Developmental*
  • Hair Cells, Auditory / cytology*
  • Hair Cells, Auditory / physiology*
  • History, 20th Century
  • History, 21st Century
  • Humans
  • Mammals / embryology*
  • Mammals / physiology*
  • Mice
  • Nerve Regeneration*