The effects of wild thyme (Thymus serpyllum L.) essential oil components against ochratoxin-producing Aspergilli

Arh Hig Rada Toksikol. 2012 Dec;63(4):457-62. doi: 10.2478/10004-1254-63-2012-2309.


The aim of this study was to determine the effects of the essential oil of Thymus serpyllum L. and of its components thymol and total phenols (total phenolic content, TPC) extracted from the plant on the growth and mycotoxin production of Aspergillus ochraceus, A. carbonarius, and A. niger. Minimal inhibitory concentration (MIC) determined for the essential oil and thymol, and selected concentration of the TPC extract inhibited fungal growth and ochratoxin A biosynthesis by more than 60 %, depending on the conditions and duration of incubation with the fungi. Essential oil showed the strongest inhibitory effect which may have been related to the synergistic or cumulative effects of its components.

MeSH terms

  • Antifungal Agents / pharmacology*
  • Aspergillus / drug effects*
  • Aspergillus / growth & development
  • Aspergillus / metabolism*
  • Microbial Sensitivity Tests
  • Ochratoxins / biosynthesis*
  • Oils, Volatile / pharmacology*
  • Plant Oils / pharmacology*
  • Thymol / pharmacology
  • Thymus Plant*


  • Antifungal Agents
  • Ochratoxins
  • Oils, Volatile
  • Plant Oils
  • Thymol