2β-deoxy-Kdo is an inhibitor of the Arabidopsis thaliana CMP-2-Keto-3-deoxymanno-octulosonic acid synthetase, the enzyme required for activation of Kdo prior to incorporation into rhamnogalacturonan II

Mol Plant. 2013 May;6(3):981-4. doi: 10.1093/mp/sst011. Epub 2013 Jan 18.
No abstract available

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Arabidopsis / drug effects
  • Arabidopsis / enzymology*
  • Arabidopsis / growth & development
  • Arabidopsis Proteins / antagonists & inhibitors*
  • Arabidopsis Proteins / metabolism
  • Biocatalysis / drug effects
  • Cell Wall / drug effects
  • Cell Wall / metabolism
  • Dimerization
  • Enzyme Inhibitors / pharmacology*
  • Kinetics
  • Mutation / genetics
  • Nucleotidyltransferases / antagonists & inhibitors*
  • Nucleotidyltransferases / metabolism
  • Pectins / metabolism*
  • Phenotype
  • Plant Roots / drug effects
  • Plant Roots / growth & development
  • Sugar Acids / pharmacology*

Substances

  • Arabidopsis Proteins
  • Enzyme Inhibitors
  • Sugar Acids
  • rhamnogalacturonan II
  • 2,6-anhydro-3-deoxyoctonate
  • Pectins
  • Nucleotidyltransferases
  • 3-deoxy-manno-octulosonate cytidyltransferase