Two apparently healthy children from the same family were found to have moderate to heavy Blastocystis hominis in their stool samples whilst being investigated for intestinal symptoms: sporadic, painless, rectal bleeding in one and persistent diarrhoea in the other. After treatment with metronidazole, they had no further signs, and stool samples became negative. Eighteen months later, both were asymptomatic, and stool samples continued to be negative for the parasite.