New tricks for old dogmas: optogenetic and designer receptor insights for Parkinson's disease

Brain Res. 2013 May 20;1511:153-63. doi: 10.1016/j.brainres.2013.01.021. Epub 2013 Jan 18.

Abstract

Optogenetics and novel designer receptors have revolutionized the way neuroscientists can interrogate neural circuits. These new tools are being rapidly applied to many facets of neuroscience including the study of Parkinson's disease circuitry and therapies. This review highlights how optogenetics and designer receptors can be applied in the study of Parkinsonian dysfunction to understand the mechanisms behind motor and non-motor symptoms. We discuss how these tools have recently advanced our understanding of basal ganglia function and outline how they can be applied in future to refine existing treatments and generate novel therapeutic strategies for Parkinson's disease. This article is part of a Special Issue entitled Optogenetics (7th BRES).

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Basal Ganglia / physiology*
  • Designer Drugs / pharmacology
  • Humans
  • Neural Pathways
  • Optogenetics*
  • Parkinson Disease* / genetics
  • Parkinson Disease* / metabolism
  • Parkinson Disease* / therapy

Substances

  • Designer Drugs