Effect of diets high in butter, corn oil, or high-oleic acid sunflower oil on serum lipids and apolipoproteins in men

Am J Clin Nutr. 1990 May;51(5):815-21. doi: 10.1093/ajcn/51.5.815.


This randomized blind crossover study compared serum lipid and apolipoprotein concentrations in 20 men consuming 37-43% of energy as fat from diets based on corn oil, high-oleic acid sunflower oil, and butter. Each phase of the crossover design included 2 wk of butter-based diet followed by 5 wk of designated vegetable-oil-based diet with a 7-wk washout period between phases. Compared with values for the butter-based diet, the vegetable-oil-based diets reduced serum total cholesterol by 16-21% (p less than 0.001), LDL cholesterol by 21-26% (p less than 0.001), triglycerides by 10-21% (p less than 0.01 for the higher figure), and apolipoprotein B-100 by 22-29% (p less than 0.001). When values fell, they fell further on the corn-oil-based diet. There were no significant changes in serum HDL cholesterol or apolipoprotein A-1. These data suggest that when men on diets high in saturated fatty acids reduce their saturated fatty acid intake but not their total fat intake, many can still experience a significant lowering in serum total cholesterol.

Publication types

  • Clinical Trial
  • Comparative Study
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Apolipoproteins / blood*
  • Butter
  • Cholesterol, HDL / blood*
  • Corn Oil / administration & dosage*
  • Dietary Fats / administration & dosage*
  • Humans
  • Lipids / blood*
  • Male
  • Oleic Acids / administration & dosage*
  • Plant Oils / administration & dosage*
  • Random Allocation


  • Apolipoproteins
  • Cholesterol, HDL
  • Dietary Fats
  • Lipids
  • Oleic Acids
  • Plant Oils
  • Corn Oil
  • Butter