Abstract
The synthesis and characterization of cationic ruthenium(II) complexes of the type [Ru(η(6)-p-cym)Cl{Ph(2)P(CH(2))(n)S(O)(x)Ph-κP,κS}][PF(6)] (n = 1-3; x = 0, 1; p-cym = p-cymene) are presented. Furthermore, their high biological potential even against cisplatin-resistant tumor cell lines and their structure-activity relationships are discussed.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents / chemical synthesis*
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / pharmacology*
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Cell Line, Tumor
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Cell Survival / drug effects
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Coordination Complexes / chemical synthesis*
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Coordination Complexes / chemistry
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Coordination Complexes / pharmacology*
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Humans
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Inhibitory Concentration 50
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Magnetic Resonance Spectroscopy
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Models, Molecular
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Organophosphorus Compounds / chemical synthesis*
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Organophosphorus Compounds / chemistry
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Organophosphorus Compounds / pharmacology
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Ruthenium / chemistry*
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Ruthenium / pharmacology
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Structure-Activity Relationship
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Sulfides / chemical synthesis*
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Sulfides / chemistry
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Sulfides / pharmacology
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Sulfoxides / chemical synthesis*
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Sulfoxides / chemistry
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Sulfoxides / pharmacology
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X-Ray Diffraction
Substances
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Antineoplastic Agents
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Coordination Complexes
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Organophosphorus Compounds
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Sulfides
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Sulfoxides
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Ruthenium