Malformational complex in an infant with intrauterine influenza viral infection

Arch Pathol Lab Med. 1990 May;114(5):535-8.


An infant with complex malformations of the central nervous system is described. The abnormalities included ependymal damage, aqueduct forking, hydrocephalus, and neuronal heterotopias; agenesis of the cerebellum, pontine, and inferior olivary neutrons; agenesis of the optic and olfactory systems and corpus callosum; and a highly unusual course of the corticospinal fibers in the spinal cord. Immunohistochemical test results showed the presence of influenza virus antigens in the brain. Possible pathogenetic mechanisms are presented.

Publication types

  • Case Reports

MeSH terms

  • Abnormalities, Multiple / etiology*
  • Antigens, Viral / analysis
  • Brain / metabolism
  • Central Nervous System / abnormalities*
  • Central Nervous System / metabolism
  • Central Nervous System / pathology
  • Female
  • Fetal Diseases* / immunology
  • Humans
  • Immunohistochemistry
  • Infant, Newborn
  • Influenza, Human / complications*
  • Influenza, Human / congenital
  • Influenza, Human / immunology
  • Orthomyxoviridae / immunology


  • Antigens, Viral