Health-related quality of life among adolescents: a comparison between subjects at risk for psychosis and other help seekers

Early Interv Psychiatry. 2014 May;8(2):163-9. doi: 10.1111/eip.12033. Epub 2013 Jan 24.


Aim: Schizophrenia is a severe illness associated with poor health-related quality of life (HRQoL), and there is some evidence that a risk state for psychosis is associated with decreased HRQoL. The aim of the present study was to investigate group differences in HRQoL in help seekers at risk for psychosis and not at risk for psychosis.

Methods: The data were collected by a Finnish early detection and intervention team at Helsinki University Central Hospital. A total of 202 help-seeking adolescents (110 girls, 92 boys; 11-22 years of age) were assessed with a PROD screen and HRQoL scale of 16D.

Results: As the main result, subjects at risk for psychosis had a poorer HRQoL index than other help seekers (P < 0.001). An additional analysis of sub-items for the HRQoL at-risk group had poorer mean scores at a statistically significant level after Bonferroni correction for multiple tests in the following sub-items: vitality (P = 0.016), distress (P = 0.016), physical appearance (P < 0.001), school and hobbies (P = 0.016), friends (P = 0.048), mental function (P < 0.001) and depression (P < 0.001). In a logistic regression analysis of sub-items of the HRQoL scale, lower scores in the sub-item of mental function independently explained the at-risk status for psychosis (P = 0.009).

Conclusions: Adolescents at risk for psychosis have a poorer HRQoL index than other help seekers and they also differ in several sub-items, particularly in the lower scores in mental function. In the future, these findings should be considered in the care of adolescents at risk for psychosis.

Keywords: adolescents; health-related quality of life; risk for psychosis.

MeSH terms

  • Adolescent
  • Adolescent Behavior / psychology*
  • Case-Control Studies
  • Child
  • Female
  • Health Status*
  • Humans
  • Male
  • Prodromal Symptoms
  • Psychotic Disorders / psychology*
  • Quality of Life / psychology*
  • Young Adult