Effects of Acute Systemic Administration of Cannabidiol on Sleep-Wake Cycle in Rats

J Psychopharmacol. 2013 Mar;27(3):312-6. doi: 10.1177/0269881112474524. Epub 2013 Jan 23.

Abstract

Cannabidiol (CBD) is one of the main components of Cannabis sativa and has a wide spectrum of action, including effects in the sleep-wake cycle.

Objective: The objective of this paper is to assess the effects on sleep of acute systemic administration of CBD.

Method: Adult male Wistar rats were randomly distributed into four groups that received intraperitoneal injections of CBD 2.5 mg/kg, CBD 10 mg/kg, CBD 40 mg/kg or vehicle (n=seven animals/group). Sleep recordings were made during light and dark periods for four days: two days of baseline recording, one day of drug administration (test), and one day after drug (post-test).

Results: During the light period of the test day, the total percentage of sleep significantly increased in the groups treated with 10 and 40 mg/kg of CBD compared to placebo. REM sleep latency increased in the group injected with CBD 40 mg/kg and was significantly decreased with the dose of 10 mg/kg on the post-test day. There was an increase in the time of SWS in the group treated with CBD 40 mg/kg, although this result did not reach statistical significance.

Conclusion: The systemic acute administration of CBD appears to increase total sleep time, in addition to increasing sleep latency in the light period of the day of administration.

MeSH terms

  • Animals
  • Antidepressive Agents / administration & dosage
  • Antidepressive Agents / adverse effects
  • Antidepressive Agents / pharmacology
  • Cannabidiol / administration & dosage*
  • Cannabidiol / adverse effects
  • Cannabidiol / pharmacology
  • Dose-Response Relationship, Drug
  • Hypnotics and Sedatives / administration & dosage*
  • Hypnotics and Sedatives / adverse effects
  • Hypnotics and Sedatives / pharmacology
  • Injections, Intraperitoneal
  • Male
  • Random Allocation
  • Rats
  • Rats, Wistar
  • Sleep / drug effects*
  • Sleep, REM / drug effects
  • Wakefulness / drug effects*

Substances

  • Antidepressive Agents
  • Hypnotics and Sedatives
  • Cannabidiol